PT666. Check an effeciency About the Suvorexant with Combining Other Sleep Promoting Medicines

s | 43 nights of wrist actigraphy. The mean age was 54.3 years (range 34 to 83). To reveal factors associated with insulin resistance and age, statistically significant variables in univariate regression analyses were entered into multivariate regression analyses. Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). In women, higher sleep onset latency (SOL) was associated with higher insulin resistance after adjustment for possible confounding factors including age, smoking, obesity, diabetes, depression, and inflammatory cytokines. Also, higher SOL was associated with higher interleukin (IL)-6 and C-reactive protein (CRP) levels. After adjusting for covariates, no sleep measures were associated with insulin resistance, IL-6, or CRP in men. The mediation analysis showed that higher SOL is associated with insulin resistance both directly and indirectly. Difficulty initiating sleep contributes to insulin resistance development, especially in middle-aged women. A combination of inflammatory pathway activation and physiological hyperarousal may be one of the key underlying mechanisms. PT665 Prevalence of Sleep Problems and Its Impact on Anxiety, Depression and Quality of Life in Korean Fire Fighters Young-Suck Paik, M.D., Ph.D.1, Kuy-Hang Lee, M.D., Ph.D.1, Hye-Jin Lee, Ph.D.,2, Sang Yeol Lee, M.D.,Ph.D. 1 1Department of Psychiatry, Wonkwang University School of Medicine, Iksan, Korea Wonkwang Brain, Behavior and Mental Health Institute 2Department of Public Health, Wonkwang University Graduate School,